View Important Safety Information

Prescribing Information


Match the dose to the individual
patient’s needs

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Patient Weight (kg)
Patient Weight (lbs)
Recommended dosing and titration schedule
(each dose to be given 3 times daily)
Dose Level Approx. Dose, by Weight mg mL
1 (~0.02 mg/kg) mg mL
2 (~0.04 mg/kg) mg mL
3 (~0.06 mg/kg) mg mL
4 (~0.08 mg/kg) mg mL
5 (~0.10 mg/kg) mg mL

Dosing Instructions for CUVPOSA

  • CUVPOSA must be administered by caregivers or clinicians with an accurate measuring device
  • CUVPOSA should be dosed at least 1 hour before or 2 hours after meals
    – The presence of high-fat food reduces the oral bioavailability of CUVPOSA if taken shortly after a meal
  • Initiate dosing of CUVPOSA at 0.02 mg/kg orally 3 times daily

Titration Instructions for CUVPOSA

  • CUVPOSA should be titrated over a 4-week period based on therapeutic response and adverse reactions in increments of 0.02 mg/kg every 5 to 7 days according to the recommended dose titration schedule
  • The maximum recommended dosage is 0.1 mg/kg 3 times daily (not to exceed 1.5 to 3.0 mg per dose based upon weight)
    – For greater details, please see the full Prescribing Information
  • Prescribers should review the tolerability of the current dose level with the patient's caregiver prior to any dose increase